譜析（上海）生物科技有限公司提供——Atypical Neuroleptics in Plasma /Serum, on-line Analysis 質譜診斷方案
2022/3/4 17:29:25
譜析（上海）生物科技有限公司提供——Atypical Neuroleptics in Plasma /Serum, on-line Analysis 質譜診斷方案
一、說明
The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone) belong to the class of the so called "atypical" neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food are factors that extensively influence their metabolism and thus lead to a high intraand interindividual variability of drug concentrations in blood. In order to avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug monitoring (TDM) is required. The RECIPE Complete Kit represents a fully automated, robust on-line SPE technique, a direct sample injection into the HPLC system.
二、產品優勢
（1）Fully automated method
（2）On-line sample preparation
（3）100 % recovery
三、測試數據
Linearity: Olz/ D-Olz:
5/ 10-1000 μg/l
Clz / D-Clz:
6/5- 5000 μg/l
Qtp: 10 - 2000 μg/l
Plp, Rsp: 1 - 200 μg/l
Recovery: 100 %
LOD: 2 μg/l (Olz, Clz, D-Clz),
4 μg/I (D-Olz, Qtp)
0.4 μg/l (Plp, Rsp)
LLOQ: 5 μg/l (Olz), 6 μg/1 (Clz),
10 μg/I (D-Olz, Qtp),
4 μg/I (D-Clz)
1 μg/1 (Plp, Rsp)
Intraassay precision: 0.2 -2%
Interassay precision: 1- 6%
四、高效液相色譜參數
A: Determination of Olz, D-Olz, Clz, D-Clz, Qtp
B: Determination of Plp, Rsp
Isocratic pump 1
(SPE-buffer): flow rates: 0.5/ 1.0 ml/min
Isocratic pump 2
(mobile phase): flow rate: A: 1.3 ml/min
B: 1.0 ml/min
Switching valve: 6-port/3-channel
(order no. FK1102)
Injection volume: A: 250 μl, B: 750 μl
Injection interval: A: 22 min, B: 20 min
UV-detector: A: 254 nm, B: 280 nm
HPLC-thermostat: 30 °C
五、樣品制備
六、訂購信息
更多產品請咨詢譜析（上海）生物科技有限公司。
網址： www.nfzsxb.cn
電話：021-58116080
手機：17717017426 陳經理 18019263206 陸經理
譜析（上海）生物科技有限公司，您實驗室試劑供應專家，歡迎咨詢詳談。
一、說明
The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone) belong to the class of the so called "atypical" neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food are factors that extensively influence their metabolism and thus lead to a high intraand interindividual variability of drug concentrations in blood. In order to avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug monitoring (TDM) is required. The RECIPE Complete Kit represents a fully automated, robust on-line SPE technique, a direct sample injection into the HPLC system.
二、產品優勢
（1）Fully automated method
（2）On-line sample preparation
（3）100 % recovery
三、測試數據
Linearity: Olz/ D-Olz:
5/ 10-1000 μg/l
Clz / D-Clz:
6/5- 5000 μg/l
Qtp: 10 - 2000 μg/l
Plp, Rsp: 1 - 200 μg/l
Recovery: 100 %
LOD: 2 μg/l (Olz, Clz, D-Clz),
4 μg/I (D-Olz, Qtp)
0.4 μg/l (Plp, Rsp)
LLOQ: 5 μg/l (Olz), 6 μg/1 (Clz),
10 μg/I (D-Olz, Qtp),
4 μg/I (D-Clz)
1 μg/1 (Plp, Rsp)
Intraassay precision: 0.2 -2%
Interassay precision: 1- 6%
四、高效液相色譜參數
A: Determination of Olz, D-Olz, Clz, D-Clz, Qtp
B: Determination of Plp, Rsp
Isocratic pump 1
(SPE-buffer): flow rates: 0.5/ 1.0 ml/min
Isocratic pump 2
(mobile phase): flow rate: A: 1.3 ml/min
B: 1.0 ml/min
Switching valve: 6-port/3-channel
(order no. FK1102)
Injection volume: A: 250 μl, B: 750 μl
Injection interval: A: 22 min, B: 20 min
UV-detector: A: 254 nm, B: 280 nm
HPLC-thermostat: 30 °C
五、樣品制備
六、訂購信息
更多產品請咨詢譜析（上海）生物科技有限公司。
網址： www.nfzsxb.cn
電話：021-58116080
手機：17717017426 陳經理 18019263206 陸經理
譜析（上海）生物科技有限公司，您實驗室試劑供應專家，歡迎咨詢詳談。
